Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC4317847 | biostudies-other | 2014 Aug
REPOSITORIES: biostudies-other
Zhang Hui H Zhang Yun-Kai YK Wang Yi-Jun YJ Kathawala Rishil J RJ Patel Atish A Zhu Hua H Sodani Kamlesh K Talele Tanaji T TT Ambudkar Suresh V SV Chen Zhe-Sheng ZS Fu Li-Wu LW
Cancer science 20140821 8
ATP-binding cassette (ABC) transmembrane proteins evidently decrease the intracellular accumulation of substrate chemotherapeutic drugs by extruding them against a concentration gradient, thereby inducing drug resistance. Here we reported the effect of WHI-P154, an irreversible inhibitor of Janus kinase 3 and epidermal growth factor receptor tyrosine kinases, on reversing ABC transporters-mediated drug resistance. We found that WHI-P154 significantly enhanced the sensitivity of ABCG2-overexpress ...[more]