Ontology highlight
ABSTRACT:
SUBMITTER: VanderWeele DJ
PROVIDER: S-EPMC4317857 | biostudies-other | 2014 Aug
REPOSITORIES: biostudies-other
VanderWeele David J DJ Brown Christopher D CD Taxy Jerome B JB Gillard Marc M Hatcher David M DM Tom Westin R WR Stadler Walter M WM White Kevin P KP
Cancer science 20140801 8
Understanding the developmental relationship between indolent and aggressive tumors is central to understanding disease progression and making treatment decisions. For example, most men diagnosed with prostate cancer have clinically indolent disease and die from other causes. Overtreatment of prostate cancer remains a concern. Here we use laser microdissection followed by exome sequencing of low- and high-grade prostate cancer foci from four subjects, and metastatic disease from two of those sub ...[more]