Ontology highlight
ABSTRACT:
SUBMITTER: Egelman EH
PROVIDER: S-EPMC4318749 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Egelman E H EH Xu C C DiMaio F F Magnotti E E Modlin C C Yu X X Wright E E Baker D D Conticello V P VP
Structure (London, England : 1993) 20150122 2
Numerous instances can be seen in evolution in which protein quaternary structures have diverged while the sequences of the building blocks have remained fairly conserved. However, the path through which such divergence has taken place is usually not known. We have designed two synthetic 29-residue α-helical peptides, based on the coiled-coil structural motif, that spontaneously self-assemble into helical nanotubes in vitro. Using electron cryomicroscopy with a newly available direct electron de ...[more]