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Immunotargeting of cancer stem cells.

ABSTRACT: Cancer stem cells (CSCs) represent a distinctive population of tumour cells that control tumour initiation, progression, and maintenance. Their influence is great enough to risk the statement that successful therapeutic strategy must target CSCs in order to eradicate the disease. Because cancer stem cells are highly resistant to chemo- and radiotherapy, new tools to fight against cancer have to be developed. Expression of antigens such as ALDH, CD44, EpCAM, or CD133, which distinguish CSCs from normal cells, together with CSC immunogenicity and relatively low toxicity of immunotherapies, makes immune targeting of CSCs a promising approach for cancer treatment. This review will present immunotherapeutic approaches using dendritic cells, T cells, pluripotent stem cells, and monoclonal antibodies to target and eliminate CSCs.

SUBMITTER: Kwiatkowska-Borowczyk EP

PROVIDER: S-EPMC4322523 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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Immunotargeting of cancer stem cells.

Kwiatkowska-Borowczyk Eliza P EP Gąbka-Buszek Agnieszka A Jankowski Jakub J Mackiewicz Andrzej A

Contemporary oncology (Poznan, Poland) 20150101 1A

Cancer stem cells (CSCs) represent a distinctive population of tumour cells that control tumour initiation, progression, and maintenance. Their influence is great enough to risk the statement that successful therapeutic strategy must target CSCs in order to eradicate the disease. Because cancer stem cells are highly resistant to chemo- and radiotherapy, new tools to fight against cancer have to be developed. Expression of antigens such as ALDH, CD44, EpCAM, or CD133, which distinguish CSCs from ...[more]

PMID: 25691822

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