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New strategies in lung cancer: epigenetic therapy for non-small cell lung cancer.

ABSTRACT: Recent discoveries that non-small cell lung cancer (NSCLC) can be divided into molecular subtypes based on the presence or absence of driver mutations have revolutionized the treatment of many patients with advanced disease. However, despite these advances, a majority of patients are still dependent on modestly effective cytotoxic chemotherapy to provide disease control and prolonged survival. In this article, we review the current status of attempts to target the epigenome, heritable modifications of DNA, histones, and chromatin that may act to modulate gene expression independently of DNA coding alterations, in NSCLC and the potential for combinatorial and sequential treatment strategies.

SUBMITTER: Forde PM

PROVIDER: S-EPMC4325981 | biostudies-other | 2014 May

REPOSITORIES: biostudies-other

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New strategies in lung cancer: epigenetic therapy for non-small cell lung cancer.

Forde Patrick M PM Brahmer Julie R JR Kelly Ronan J RJ

Clinical cancer research : an official journal of the American Association for Cancer Research 20140318 9

Recent discoveries that non-small cell lung cancer (NSCLC) can be divided into molecular subtypes based on the presence or absence of driver mutations have revolutionized the treatment of many patients with advanced disease. However, despite these advances, a majority of patients are still dependent on modestly effective cytotoxic chemotherapy to provide disease control and prolonged survival. In this article, we review the current status of attempts to target the epigenome, heritable modificati ...[more]

PMID: 24644000

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