Endoplasmic reticulum stress activates telomerase.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC4326870 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Publications
Endoplasmic reticulum stress activates telomerase.
Zhou Junzhi J Mao Beibei B Zhou Qi Q Ding Deqiang D Wang Miao M Guo Peng P Gao Yuhao Y Shay Jerry W JW Yuan Zengqiang Z Cong Yu-Sheng YS
Aging cell 20131022 1
Telomerase contributes to cell proliferation and survival through both telomere-dependent and telomere-independent mechanisms. In this report, we discovered that endoplasmic reticulum (ER) stress transiently activates the catalytic components of telomerase (TERT) expression in human cancer cell lines and murine primary neural cells. Importantly, we show that depletion of hTERT sensitizes cells to undergo apoptosis under ER stress, whereas increased hTERT expression reduces ER stress-induced cell ...[more]
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