Ontology highlight
ABSTRACT:
SUBMITTER: Ai L
PROVIDER: S-EPMC4329918 | biostudies-other | 2014 Sep
REPOSITORIES: biostudies-other
Ai Lingbao L Kim Wan-Ju WJ Alpay Merve M Tang Ming M Pardo Carolina E CE Hatakeyama Shigetsugu S May W Stratford WS Kladde Michael P MP Heldermon Coy D CD Siegel Erin M EM Brown Kevin D KD
Cancer research 20140620 17
TRIM29 (ATDC) exhibits a contextual function in cancer, but seems to exert a tumor-suppressor role in breast cancer. Here, we show that TRIM29 is often silenced in primary breast tumors and cultured tumor cells as a result of aberrant gene hypermethylation. RNAi-mediated silencing of TRIM29 in breast tumor cells increased their motility, invasiveness, and proliferation in a manner associated with increased expression of mesenchymal markers (N-cadherin and vimentin), decreased expression of epith ...[more]