Ontology highlight
ABSTRACT:
SUBMITTER: Ren J
PROVIDER: S-EPMC4330352 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Ren Jianke J Briones Victorino V Barbour Samantha S Yu Weishi W Han Yixing Y Terashima Minoru M Muegge Kathrin K
Nucleic acids research 20150110 3
Lsh, a chromatin remodeling protein of the SNF2 family, is critical for normal heterochromatin structure. In particular, DNA methylation at repeat elements, a hallmark of heterochromatin, is greatly reduced in Lsh(-/-) (KO) cells. Here, we examined the presumed nucleosome remodeling activity of Lsh on chromatin in the context of DNA methylation. We found that dynamic CG methylation was dependent on Lsh in embryonic stem cells. Moreover, we demonstrate that ATP function is critical for de novo me ...[more]