Ontology highlight
ABSTRACT:
SUBMITTER: Antonini D
PROVIDER: S-EPMC4333422 | biostudies-other | 2015 Jan
REPOSITORIES: biostudies-other
Antonini Dario D Sirico Anna A Aberdam Edith E Ambrosio Raffaele R Campanile Carmen C Fagoonee Sharmila S Altruda Fiorella F Aberdam Daniel D Brissette Janice L JL Missero Caterina C
Nucleic acids research 20150107 2
p63 is a crucial regulator of epidermal development, but its transcriptional control has remained elusive. Here, we report the identification of a long-range enhancer (p63LRE) that is composed of two evolutionary conserved modules (C38 and C40), acting in concert to control tissue- and layer-specific expression of the p63 gene. Both modules are in an open and active chromatin state in human and mouse keratinocytes and in embryonic epidermis, and are strongly bound by p63. p63LRE activity is depe ...[more]