Ontology highlight
ABSTRACT:
SUBMITTER: Badie S
PROVIDER: S-EPMC4339125 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Badie Sophie S Carlos Ana Rita AR Folio Cecilia C Okamoto Keiji K Bouwman Peter P Jonkers Jos J Tarsounas Madalena M
The EMBO journal 20150112 3
Loss of telomere protection occurs during physiological cell senescence and ageing, due to attrition of telomeric repeats and insufficient retention of the telomere-binding factor TRF2. Subsequently formed telomere fusions trigger rampant genomic instability leading to cell death or tumorigenesis. Mechanistically, telomere fusions require either the classical non-homologous end-joining (C-NHEJ) pathway dependent on Ku70/80 and LIG4, or the alternative non-homologous end-joining (A-NHEJ), which r ...[more]