Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung.
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ABSTRACT:
SUBMITTER: Fields RJ
PROVIDER: S-EPMC4339402 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Publications
Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung.
Fields Rachel J RJ Quijano Elias E McNeer Nicole Ali NA Caputo Christina C Bahal Raman R Anandalingam Kavi K Egan Marie E ME Glazer Peter M PM Saltzman W Mark WM
Advanced healthcare materials 20140825 3
Surface-modified poly(lactic-co-glycolic acid) (PLGA)/poly(β-aminoester)(PBAE)nanoparticles (NPs) have shown great promise in gene delivery. In this work, the pulmonary cellular uptake of these NPs is evaluated and surface-modified PLGA/PBAE NPs are shown to achieve higher cellular association and gene editing than traditional NPs composed of PLGA or PLGA/PBAE blends alone. ...[more]
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