Ontology highlight
ABSTRACT:
SUBMITTER: Miller MM
PROVIDER: S-EPMC4340460 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Miller Misty M MM Liedtke Michelle D MD Lockhart Staci M SM Rathbun R Chris RC
Infection and drug resistance 20150219
Dolutegravir is the most recent integrase strand transfer inhibitor approved for HIV-1 infection in both treatment-naïve and experienced patients. As a tricyclic carbamoyl pyridone analog, dolutegravir is rapidly absorbed and distributes through the cerebrospinal fluid. It is hepatically metabolized by uridine diphosphate glucuronosyl transferase 1A1; no inhibition or induction of cytochrome P450 enzymes is noted. As a substrate of CYP 3A4, dolutegravir is affected by rifampin, efavirenz, tipran ...[more]