Ontology highlight
ABSTRACT:
SUBMITTER: Kim YJ
PROVIDER: S-EPMC4344203 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Kim Young-Jun YJ Igiesuorobo Oghomwen O Ramos Cathy I CI Bao Hong H Zhang Bing B Serpe Mihaela M
PLoS genetics 20150227 2
Stabilization of neurotransmitter receptors at postsynaptic specializations is a key step in the assembly of functional synapses. Drosophila Neto (Neuropillin and Tolloid-like protein) is an essential auxiliary subunit of ionotropic glutamate receptor (iGluR) complexes required for the iGluRs clustering at the neuromuscular junction (NMJ). Here we show that optimal levels of Neto are crucial for stabilization of iGluRs at synaptic sites and proper NMJ development. Genetic manipulations of Neto l ...[more]