Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharya M
PROVIDER: S-EPMC4347230 | biostudies-other | 2014 Nov
REPOSITORIES: biostudies-other
Bhattacharya Mallar M Sundaram Aparna A Kudo Makoto M Farmer Jessica J Ganesan Previn P Khalifeh-Soltani Amin A Arjomandi Mehrdad M Atabai Kamran K Huang Xiaozhu X Sheppard Dean D
The Journal of clinical investigation 20141001 11
The intracellular scaffold protein IQGAP1 supports protein complexes in conjunction with numerous binding partners involved in multiple cellular processes. Here, we determined that IQGAP1 modulates airway smooth muscle contractility. Compared with WT controls, at baseline as well as after immune sensitization and challenge, Iqgap1-/- mice had higher airway responsiveness. Tracheal rings from Iqgap1-/- mice generated greater agonist-induced contractile force, even after removal of the epithelium. ...[more]