Ontology highlight
ABSTRACT:
SUBMITTER: Berger M
PROVIDER: S-EPMC4352814 | biostudies-other | 2015 Mar
REPOSITORIES: biostudies-other
Berger Miles M Scheel David W DW Macias Hector H Miyatsuka Takeshi T Kim Hail H Hoang Phuong P Ku Greg M GM Honig Gerard G Liou Angela A Tang Yunshuo Y Regard Jean B JB Sharifnia Panid P Yu Lisa L Wang Juehu J Coughlin Shaun R SR Conklin Bruce R BR Deneris Evan S ES Tecott Laurence H LH German Michael S MS
Proceedings of the National Academy of Sciences of the United States of America 20150218 9
Gi-GPCRs, G protein-coupled receptors that signal via Gα proteins of the i/o class (Gαi/o), acutely regulate cellular behaviors widely in mammalian tissues, but their impact on the development and growth of these tissues is less clear. For example, Gi-GPCRs acutely regulate insulin release from pancreatic β cells, and variants in genes encoding several Gi-GPCRs--including the α-2a adrenergic receptor, ADRA2A--increase the risk of type 2 diabetes mellitus. However, type 2 diabetes also is associa ...[more]