Ontology highlight
ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC4352890 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Zhang Pengju P Lo Alvin A Huang Yurong Y Huang Ge G Liang Guozhou G Mott Joni J Karpen Gary H GH Blakely Eleanor A EA Bissell Mina J MJ Barcellos-Hoff Mary Helen MH Snijders Antoine M AM Mao Jian-Hua JH
Scientific reports 20150309
The interplay between host genetics, tumor microenvironment and environmental exposure in cancer susceptibility remains poorly understood. Here we assessed the genetic control of stromal mediation of mammary tumor susceptibility to low dose ionizing radiation (LDIR) using backcrossed F1 into BALB/c (F1Bx) between cancer susceptible (BALB/c) and resistant (SPRET/EiJ) mouse strains. Tumor formation was evaluated after transplantation of non-irradiated Trp53-/- BALB/c mammary gland fragments into c ...[more]