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Luminescent ruthenium(II) complex bearing bipyridine and N-heterocyclic carbene-based C?N?C pincer ligand for live-cell imaging of endocytosis.

ABSTRACT: Luminescent ruthenium(II)-cyanide complex with N-heterocyclic carbene pincer ligand C(?)N(?)C = 2,6-bis(1-butylimidazol-2-ylidene)pyridine and 2,2'-bipyridine (bpy) shows minimal cytotoxicity to both human breast carcinoma cell (MCF-7) and human retinal pigmented epithelium cell (RPE) in a wide range of concentration (0.1-500??M), and can be used for the luminescent imaging of endocytosis of the complex in these cells.

SUBMITTER: Tsui WK

PROVIDER: S-EPMC4357851 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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Luminescent ruthenium(II) complex bearing bipyridine and N-heterocyclic carbene-based C∧N∧C pincer ligand for live-cell imaging of endocytosis.

Tsui Wai-Kuen WK Chung Lai-Hon LH Wong Matthew Man-Kin MM Tsang Wai-Him WH Lo Hoi-Shing HS Liu Yaxiang Y Leung Chung-Hang CH Ma Dik-Lung DL Chiu Sung-Kay SK Wong Chun-Yuen CY

Scientific reports 20150313

Luminescent ruthenium(II)-cyanide complex with N-heterocyclic carbene pincer ligand C(∧)N(∧)C = 2,6-bis(1-butylimidazol-2-ylidene)pyridine and 2,2'-bipyridine (bpy) shows minimal cytotoxicity to both human breast carcinoma cell (MCF-7) and human retinal pigmented epithelium cell (RPE) in a wide range of concentration (0.1-500 μM), and can be used for the luminescent imaging of endocytosis of the complex in these cells. ...[more]

PMID: 25765974

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