Ontology highlight
ABSTRACT:
SUBMITTER: Zhou M
PROVIDER: S-EPMC4359230 | biostudies-other | 2015 Jan
REPOSITORIES: biostudies-other
Zhou Minran M Zeng Jiping J Wang Xiaoming X Wang Xiangyu X Huang Tao T Fu Yue Y Sun Ting T Jia Jihui J Chen Chunyan C
Oncotarget 20150101 2
Chronic myeloid leukemia in the blastic phase (CML-BP) responds poorly to clinical treatments and is usually fatal. In this study, we found that the histone H3 lysine 4 (H3K4) demethylase RBP2 (also called JARID1A and KDM5A) is underexpressed in CML-BP. The RBP2 histone demethylase stimulates leukemia cell differentiation and inhibits cell proliferation. We identified miR-21 was directly downregulated by RBP2 and found that miR-21 downregulated PDCD4 expression in leukemia cells. By binding to m ...[more]