Ontology highlight
ABSTRACT:
SUBMITTER: Lim J
PROVIDER: S-EPMC4361319 | biostudies-other | 2015 Apr
REPOSITORIES: biostudies-other
Lim Joohyun J Tu Xiaolin X Choi Kyunghee K Akiyama Haruhiko H Mishina Yuji Y Long Fanxin F
Developmental biology 20150129 1
Bone morphogenetic proteins (BMPs) regulate multiple aspects of skeletal development in vertebrates. Although exogenously applied BMPs can induce chondrogenesis de novo, the role and mechanism of physiologic BMP signaling during precartilaginous mesenchymal condensation is not well understood. By deleting the type I BMP receptors or the transcription factor Smad4 in the limb bud mesenchyme, we find that loss of BMP-Smad signaling abolishes skeletal development due to a failure in mesenchymal con ...[more]