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Sensitization of Gram-negative bacteria to rifampin and OAK combinations.

ABSTRACT: While individually inefficient against Gram-negative bacteria, in-vitro combinations of rifampin and OAK were mutually synergistic since sub-minimal inhibitory concentrations of one compound have potentiated the other by 2-4 orders of magnitude. Synergy persisted in-vivo as single-dose systemic treatment of Klebsiella infected mice resulted in 10-20% versus 60% survival, respectively accomplished by individual and combined compounds. This outcome was achieved without drug formulation, rather, pharmacokinetic considerations have inspired the therapeutic regimen.

SUBMITTER: Jammal J

PROVIDER: S-EPMC4363860 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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Sensitization of Gram-negative bacteria to rifampin and OAK combinations.

Jammal Joanna J Zaknoon Fadia F Kaneti Galoz G Goldberg Keren K Mor Amram A

Scientific reports 20150318

While individually inefficient against Gram-negative bacteria, in-vitro combinations of rifampin and OAK were mutually synergistic since sub-minimal inhibitory concentrations of one compound have potentiated the other by 2-4 orders of magnitude. Synergy persisted in-vivo as single-dose systemic treatment of Klebsiella infected mice resulted in 10-20% versus 60% survival, respectively accomplished by individual and combined compounds. This outcome was achieved without drug formulation, rather, ph ...[more]

PMID: 25782773

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