Ontology highlight
ABSTRACT:
SUBMITTER: Oynebraten I
PROVIDER: S-EPMC4367157 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Øynebråten Inger I Barois Nicolas N Bergeland Trygve T Küchler Axel M AM Bakke Oddmund O Haraldsen Guttorm G
Scientific reports 20150320
Vascular endothelial cells present luminal chemokines that arrest rolling leukocytes by activating integrins. It appears that several chemokines must form higher-order oligomers to elicit proper in vivo effects, as mutants restricted to forming dimers have lost the ability to recruit leukocytes to sites of inflammation. Here, we show for the first time that the chemokine RANTES/CCL5 binds to the surface of human endothelial cells in a regular filamentous pattern. Furthermore, the filaments bound ...[more]