Ontology highlight
ABSTRACT:
SUBMITTER: Hsiao V
PROVIDER: S-EPMC4384833 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
ACS synthetic biology 20140515 2
As a field, synthetic biology strives to engineer increasingly complex artificial systems in living cells. Active feedback in closed loop systems offers a dynamic and adaptive way to ensure constant relative activity independent of intrinsic and extrinsic noise. In this work, we use synthetic protein scaffolds as a modular and tunable mechanism for concentration tracking through negative feedback. Input to the circuit initiates scaffold production, leading to colocalization of a two-component sy ...[more]