Ontology highlight
ABSTRACT:
SUBMITTER: Chow HY
PROVIDER: S-EPMC4385830 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Chow Hoi-Yee HY Dong Biao B Duron Sergio G SG Campbell David A DA Ong Christy C CC Hoeflich Klaus P KP Chang Long-Sheng LS Welling D Bradley DB Yang Zeng-Jie ZJ Chernoff Jonathan J
Oncotarget 20150201 4
Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder characterized by the development of multiple tumors in the central nervous system, most notably schwannomas and meningiomas. Mutational inactivation of NF2 is found in 40-60% of sporadic meningiomas, but the molecular mechanisms underlying malignant changes of meningioma cells remain unclear. Because group I p21-activated kinases (Paks) bind to and are inhibited by the NF2-encoded protein Merlin, we assessed the signaling and anti- ...[more]