Ontology highlight
ABSTRACT:
SUBMITTER: Zamolodchikov D
PROVIDER: S-EPMC4386355 | biostudies-other | 2015 Mar
REPOSITORIES: biostudies-other
Zamolodchikov Daria D Chen Zu-Lin ZL Conti Brooke A BA Renné Thomas T Strickland Sidney S
Proceedings of the National Academy of Sciences of the United States of America 20150316 13
Alzheimer's disease (AD) is characterized by accumulation of the β-amyloid peptide (Aβ), which likely contributes to disease via multiple mechanisms. Increasing evidence implicates inflammation in AD, the origins of which are not completely understood. We investigated whether circulating Aβ could initiate inflammation in AD via the plasma contact activation system. This proteolytic cascade is triggered by the activation of the plasma protein factor XII (FXII) and leads to kallikrein-mediated cle ...[more]