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A plug-and-play ratiometric pH-sensing nanoprobe for high-throughput investigation of endosomal escape.

ABSTRACT: An important aspect in the design of nanomaterials for delivery is an understanding of its uptake and ultimate release to the cytosol of target cells. Real-time chemical sensing using a nanoparticle-based platform affords exquisite insight into the trafficking of materials and their cargo into cells. This versatile and tunable technology provides a powerful tool to probe the mechanism of cellular entry and cytosolic delivery of a variety of materials, allowing for a simple and convenient means to screen materials towards efficient delivery of therapeutics such as nucleic acids.

SUBMITTER: Deng ZJ

PROVIDER: S-EPMC4387846 | biostudies-other | 2015 May

REPOSITORIES: biostudies-other

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A plug-and-play ratiometric pH-sensing nanoprobe for high-throughput investigation of endosomal escape.

Deng Zhou J ZJ Morton Stephen W SW Bonner Daniel K DK Gu Li L Ow Hooisweng H Hammond Paula T PT

Biomaterials 20150220

An important aspect in the design of nanomaterials for delivery is an understanding of its uptake and ultimate release to the cytosol of target cells. Real-time chemical sensing using a nanoparticle-based platform affords exquisite insight into the trafficking of materials and their cargo into cells. This versatile and tunable technology provides a powerful tool to probe the mechanism of cellular entry and cytosolic delivery of a variety of materials, allowing for a simple and convenient means t ...[more]

PMID: 25771015

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