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Mechanisms and clinical consequences of untreated central sleep apnea in heart failure.


ABSTRACT: Central sleep apnea (CSA) is a highly prevalent, though often unrecognized, comorbidity in patients with heart failure (HF). Data from HF population studies suggest that it may present in 30% to 50% of HF patients. CSA is recognized as an important contributor to the progression of HF and to HF-related morbidity and mortality. Over the past 2 decades, an expanding body of research has begun to shed light on the pathophysiologic mechanisms of CSA. Armed with this growing knowledge base, the sleep, respiratory, and cardiovascular research communities have been working to identify ways to treat CSA in HF with the ultimate goal of improving patient quality of life and clinical outcomes. In this paper, we examine the current state of knowledge about the mechanisms of CSA in HF and review emerging therapies for this disorder.

SUBMITTER: Costanzo MR 

PROVIDER: S-EPMC4391015 | biostudies-other | 2015 Jan

REPOSITORIES: biostudies-other

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Mechanisms and clinical consequences of untreated central sleep apnea in heart failure.

Costanzo Maria Rosa MR   Khayat Rami R   Ponikowski Piotr P   Augostini Ralph R   Stellbrink Christoph C   Mianulli Marcus M   Abraham William T WT  

Journal of the American College of Cardiology 20150101 1


Central sleep apnea (CSA) is a highly prevalent, though often unrecognized, comorbidity in patients with heart failure (HF). Data from HF population studies suggest that it may present in 30% to 50% of HF patients. CSA is recognized as an important contributor to the progression of HF and to HF-related morbidity and mortality. Over the past 2 decades, an expanding body of research has begun to shed light on the pathophysiologic mechanisms of CSA. Armed with this growing knowledge base, the sleep  ...[more]

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