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Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.

ABSTRACT: Lymphocyte chemoattractant factor (LCF) is a lymphocyte cell product that stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. In concert with its chemoattractant activity, LCF induces human T-lymphocyte expression of interleukin 2 receptor. Here we describe the molecular cloning of cDNA encoding human LCF. It is a novel interleukin with no significant homology to any previously described cytokine families. There is an absolute requirement for both autoaggregation of LCF monomers and for membrane-expressed CD4 molecules for LCF-induced migration in lymphocytes.

SUBMITTER: Cruikshank WW

PROVIDER: S-EPMC43941 | biostudies-other | 1994 May

REPOSITORIES: biostudies-other

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Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.

Cruikshank W W WW Center D M DM Nisar N N Wu M M Natke B B Theodore A C AC Kornfeld H H

Proceedings of the National Academy of Sciences of the United States of America 19940501 11

Lymphocyte chemoattractant factor (LCF) is a lymphocyte cell product that stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. In concert with its chemoattractant activity, LCF induces human T-lymphocyte expression of interleukin 2 receptor. Here we describe the molecular cloning of cDNA encoding human LCF. It is a novel interleukin with no significant homology to any previously described cytokine families. There is an absolute requirement for both autoaggregation of ...[more]

PMID: 7910967

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