Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC4394255 | biostudies-other | 2015 Apr
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20150323 14
A long-standing hypothesis posits that a G protein-coupled signaling pathway mediates β-adrenergic nervous system functions, including learning and memory. Here we report that memory retrieval (reactivation) induces the activation of β1-adrenergic β-arrestin signaling in the brain, which stimulates ERK signaling and protein synthesis, leading to postreactivation memory restabilization. β-Arrestin2-deficient mice exhibit impaired memory reconsolidation in object recognition, Morris water maze, an ...[more]