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Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment.

ABSTRACT: Systems pharmacology modeling and pharmacokinetic-pharmacodynamic (PK/PD) analysis of drug-induced effects on cardiovascular (CV) function plays a crucial role in understanding the safety risk of new drugs. The aim of this review is to outline the current modeling and simulation (M&S) approaches to describe and translate drug-induced CV effects, with an emphasis on how this impacts drug safety assessment. Current limitations are highlighted and recommendations are made for future effort in this vital area of drug research.

SUBMITTER: Collins TA 

PROVIDER: S-EPMC4394617 | biostudies-other | 2015 Mar

REPOSITORIES: biostudies-other

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Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment.

Collins T A TA   Bergenholm L L   Abdulla T T   Yates Jwt J   Evans N N   Chappell M J MJ   Mettetal J T JT  

CPT: pharmacometrics & systems pharmacology 20150311 3

Systems pharmacology modeling and pharmacokinetic-pharmacodynamic (PK/PD) analysis of drug-induced effects on cardiovascular (CV) function plays a crucial role in understanding the safety risk of new drugs. The aim of this review is to outline the current modeling and simulation (M&S) approaches to describe and translate drug-induced CV effects, with an emphasis on how this impacts drug safety assessment. Current limitations are highlighted and recommendations are made for future effort in this  ...[more]