Ontology highlight
ABSTRACT:
SUBMITTER: Liu TY
PROVIDER: S-EPMC4403200 | biostudies-other | 2015 Apr
REPOSITORIES: biostudies-other
Liu Tina Y TY Bian Xin X Romano Fabian B FB Shemesh Tom T Rapoport Tom A TA Hu Junjie J
Proceedings of the National Academy of Sciences of the United States of America 20150330 15
Atlastin (ATL), a membrane-anchored GTPase that mediates homotypic fusion of endoplasmic reticulum (ER) membranes, is required for formation of the tubular network of the peripheral ER. How exactly ATL mediates membrane fusion is only poorly understood. Here we show that fusion is preceded by the transient tethering of ATL-containing vesicles caused by the dimerization of ATL molecules in opposing membranes. Tethering requires GTP hydrolysis, not just GTP binding, because the two ATL molecules a ...[more]