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Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever.


ABSTRACT: In testing paired serum samples from 40 consecutive cases of African tick bite fever, we detected diagnostic antibodies against spotted fever group rickettsiae in 45% of the patients by immunofluorescence assay (IFA) and in 100% of the patients by Western blotting (WB) (P < 0.01). A specific diagnosis of Rickettsia africae infection could be established in 15% of the patients by IFA and in 73% of the patients by a combination of WB and cross-adsorption assays (P < 0.01).

SUBMITTER: Jensenius M 

PROVIDER: S-EPMC440600 | biostudies-other | 2004 Jul

REPOSITORIES: biostudies-other

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2024-01-09 | GSE249650 | GEO