Ontology highlight
ABSTRACT:
SUBMITTER: Metzenberg S
PROVIDER: S-EPMC44117 | biostudies-other | 1994 Jun
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19940601 13
In a search for trypanosome DNA sequences that permit replication and stable maintenance of extrachromosomal elements, a 1-kilobase-pair (kbp) fragment from a mitochondrial kinetoplast DNA (kDNA) minicircle of Trypanosoma brucei was isolated and characterized. The plasmid pTbo-1, carrying the kDNA element, is maintained in T. brucei as a supercoiled concatemer containing approximately seven to nine pTbo-1 monomer units (5.6 kbp each) in a head-to-tail orientation. The concatemer is found in appr ...[more]