Membrane fusion during phage lysis.
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ABSTRACT:
SUBMITTER: Rajaure M
PROVIDER: S-EPMC4418876 | biostudies-other | 2015 Apr
REPOSITORIES: biostudies-other
Publications
Membrane fusion during phage lysis.
Rajaure Manoj M Rajaure Manoj M Berry Joel J Kongari Rohit R Cahill Jesse J Young Ry R
Proceedings of the National Academy of Sciences of the United States of America 20150413 17
In general, phages cause lysis of the bacterial host to effect release of the progeny virions. Until recently, it was thought that degradation of the peptidoglycan (PG) was necessary and sufficient for osmotic bursting of the cell. Recently, we have shown that in Gram-negative hosts, phage lysis also requires the disruption of the outer membrane (OM). This is accomplished by spanins, which are phage-encoded proteins that connect the cytoplasmic membrane (inner membrane, IM) and the OM. The mecha ...[more]
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