Ontology highlight
ABSTRACT:
SUBMITTER: Carreira RJ
PROVIDER: S-EPMC4422864 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Carreira Ricardo J RJ Shyti Reinald R Balluff Benjamin B Abdelmoula Walid M WM van Heiningen Sandra H SH van Zeijl Rene J RJ Dijkstra Jouke J Ferrari Michel D MD Tolner Else A EA McDonnell Liam A LA van den Maagdenberg Arn M J M AM
Journal of the American Society for Mass Spectrometry 20150416 6
Cortical spreading depression (CSD) is the electrophysiological correlate of migraine aura. Transgenic mice carrying the R192Q missense mutation in the Cacna1a gene, which in patients causes familial hemiplegic migraine type 1 (FHM1), exhibit increased propensity to CSD. Herein, mass spectrometry imaging (MSI) was applied for the first time to an animal cohort of transgenic and wild type mice to study the biomolecular changes following CSD in the brain. Ninety-six coronal brain sections from 32 ...[more]