Ontology highlight
ABSTRACT:
SUBMITTER: Li P
PROVIDER: S-EPMC4423088 | biostudies-other | 2015 May
REPOSITORIES: biostudies-other
Li Pu P Shan Jing-Xuan JX Chen Xue-Hua XH Zhang Di D Su Li-Ping LP Huang Xiu-Ying XY Yu Bei-Qin BQ Zhi Qiao-Ming QM Li Cheng-Long CL Wang Ya-Qing YQ Tomei Sara S Cai Qu Q Ji Jun J Li Jian-Fang JF Chouchane Lotfi L Yu Ying-Yan YY Sun Fang-Zhen FZ Xu Zhi-Heng ZH Liu Bing-Ya BY Zhu Zheng-Gang ZG
Cell research 20150428 5
Tumor initiation and growth depend on its microenvironment in which cancer-associated fibroblasts (CAFs) in tumor stroma play an important role. Prostaglandin E2 (PGE2) and interleukin (IL)-6 signal pathways are involved in the crosstalk between tumor and stromal cells. However, how PGE2-mediated signaling modulates this crosstalk remains unclear. Here, we show that microRNA (miR)-149 links PGE2 and IL-6 signaling in mediating the crosstalk between tumor cells and CAFs in gastric cancer (GC). mi ...[more]