Ontology highlight
ABSTRACT:
SUBMITTER: Small DM
PROVIDER: S-EPMC4426794 | biostudies-other | 2015 Jan
REPOSITORIES: biostudies-other
Small Donna M DM Zani Marie-Louise ML Quinn Derek J DJ Dallet-Choisy Sandrine S Glasgow Arlene M A AM O'Kane Cecilia C McAuley Danny F DF McNally Paul P Weldon Sinéad S Moreau Thierry T Taggart Clifford C CC
Molecular therapy : the journal of the American Society of Gene Therapy 20140905 1
Elafin is a serine protease inhibitor produced by epithelial and immune cells with anti-inflammatory properties. Research has shown that dysregulated protease activity may elicit proteolytic cleavage of elafin, thereby impairing the innate immune function of the protein. The aim of this study was to generate variants of elafin (GG- and QQ-elafin) that exhibit increased protease resistance while retaining the biological properties of wild-type (WT) elafin. Similar to WT-elafin, GG- and QQ-elafin ...[more]