Ontology highlight
ABSTRACT:
SUBMITTER: Rincon MY
PROVIDER: S-EPMC4426801 | biostudies-other | 2015 Jan
REPOSITORIES: biostudies-other
Rincon Melvin Y MY Sarcar Shilpita S Danso-Abeam Dina D Keyaerts Marleen M Matrai Janka J Samara-Kuko Ermira E Acosta-Sanchez Abel A Athanasopoulos Takis T Dickson George G Lahoutte Tony T De Bleser Pieter P VandenDriessche Thierry T Chuah Marinee K MK
Molecular therapy : the journal of the American Society of Gene Therapy 20140908 1
Gene therapy is a promising emerging therapeutic modality for the treatment of cardiovascular diseases and hereditary diseases that afflict the heart. Hence, there is a need to develop robust cardiac-specific expression modules that allow for stable expression of the gene of interest in cardiomyocytes. We therefore explored a new approach based on a genome-wide bioinformatics strategy that revealed novel cardiac-specific cis-acting regulatory modules (CS-CRMs). These transcriptional modules cont ...[more]