Ontology highlight
ABSTRACT:
SUBMITTER: Taipale K
PROVIDER: S-EPMC4427873 | biostudies-other | 2015 May
REPOSITORIES: biostudies-other
Taipale Kristian K Liikanen Ilkka I Juhila Juuso J Karioja-Kallio Aila A Oksanen Minna M Turkki Riku R Linder Nina N Lundin Johan J Ristimäki Ari A Kanerva Anna A Koski Anniina A Joensuu Timo T Vähä-Koskela Markus M Hemminki Akseli A
Molecular therapy : the journal of the American Society of Gene Therapy 20150206 5
The quality of the antitumor immune response is decisive when developing new immunotherapies for cancer. Oncolytic adenoviruses cause a potent immunogenic stimulus and arming them with costimulatory molecules reshapes the immune response further. We evaluated peripheral blood T-cell subsets of 50 patients with refractory solid tumors undergoing treatment with oncolytic adenovirus. These data were compared to changes in antiviral and antitumor T cells, treatment efficacy, overall survival, and T- ...[more]