Unknown

Dataset Information

0

The diagnostic accuracy of spectral-domain optical coherence tomography for neovascular age-related macular degeneration: a comparison with fundus fluorescein angiography.


ABSTRACT: To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) for neovascular age-related macular degeneration (nAMD): a comparison against fundus fluorescein angiography (FFA).A retrospective review of SD-OCT, colour fundus photographs (FP), and FFA of 411 consecutive patients referred to a rapid access Macular Clinic over a 4-year period was performed. FFA images were reviewed non-stereoscopically. SD-OCT images were acquired using the Topcon 3D OCT-1000 instrument. All FFA and OCT images were graded by at least two ophthalmologists independently. Side-by-side grading took place with immediate open discussion and adjudication. If there was disagreement between the two grading ophthalmologists or they were not 90% confident of their assigned grade, then adjudication by a third ophthalmologist was performed.A total of 278 eyes were graded as having choroidal neovascularisation (CNV) with SD-OCT and 231 diagnosed with FFA. The main diagnostic CNV classifications on FFA were: classic no occult in 27 eyes, predominantly classic in 16, minimally classic in 50, occult in 129, and 9 peripapillary membranes. There were a total of 47 false positives with SD-OCT: a rate of 16.9%. The sensitivity and specificity of SD-OCT alone for detecting CNV was 100 and 80.8%, respectively.Our study confirms SD-OCT in comparison to the reference standard of non-stereoscopic FFA is highly sensitive at detecting newly presenting nAMD in the setting of a specialist AMD clinic where the investigations are interpreted by trained specialists. However, it does not seem accurate enough to replace FFA in the diagnosis on nAMD in current practice.

SUBMITTER: Wilde C 

PROVIDER: S-EPMC4429282 | biostudies-other | 2015 May

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC6917758 | biostudies-literature
| S-EPMC6727912 | biostudies-literature
| S-EPMC7775057 | biostudies-literature
| S-EPMC9291450 | biostudies-literature
| S-EPMC3758459 | biostudies-literature
| S-EPMC8639888 | biostudies-literature
| S-EPMC6567979 | biostudies-literature
| S-EPMC9237881 | biostudies-literature
| S-EPMC6439851 | biostudies-literature
| S-EPMC7709243 | biostudies-literature