Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC44310 | biostudies-other | 1994 Jul
REPOSITORIES: biostudies-other
Yang X X Bani M R MR Lu S J SJ Rowan S S Ben-David Y Y Chabot B B
Proceedings of the National Academy of Sciences of the United States of America 19940701 15
Recent in vitro results suggest that the heterogeneous nuclear ribonucleoparticle (hnRNP) A1 protein modulates alternative splicing by favoring distal 5' splice site (5'SS) selection and exon skipping. We used a mouse erythroleukemia (MEL) cell line (CB3C7) deficient in the expression of hnRNP A1 to test whether variations in hnRNP A1 and AlB protein levels affected alternative splicing in vivo. In contrast to A1-expressing MEL cell lines, CB3C7 cells preferentially selected the proximal 13S and ...[more]