Ontology highlight
ABSTRACT:
SUBMITTER: Louie A
PROVIDER: S-EPMC4447837 | biostudies-other | 2015 Apr
REPOSITORIES: biostudies-other
Louie Arnold A Liu Weiguo W VanGuilder Michael M Neely Michael N MN Schumitzky Alan A Jelliffe Roger R Fikes Steven S Kurhanewicz Stephanie S Robbins Nichole N Brown David D Baluya Dodge D Drusano George L GL
The Journal of infectious diseases 20141031 8
<h4>Background</h4>Meropenem plus levofloxacin treatment was shown to be a promising combination in our in vitro hollow fiber infection model. We strove to validate this finding in a murine Pseudomonas pneumonia model.<h4>Methods</h4>A dose-ranging study with meropenem and levofloxacin alone and in combination against Pseudomonas aeruginosa was performed in a granulocytopenic murine pneumonia model. Meropenem and levofloxacin were administered to partially humanize their pharmacokinetic profiles ...[more]