Synthesis of the diaryl ether cores common to chrysophaentins A, E and F.

ABSTRACT: The synthesis of the diaryl ether subunits of the marine natural products chrysophaentin A, E and F is described. These natural prodcuts feature tetrasubstituted benzene rings with complex substitution patterns. The central strategy involves an SNAr reaction between a complex phenol and a polysubstituted fluoronitrobenzene. Subseqent attempts to construct the unusual E-chloroalkene linkage through several different approaches are also disclosed.

SUBMITTER: Brockway AJ 

PROVIDER: S-EPMC4448730 | biostudies-other | 2015 Jun

REPOSITORIES: biostudies-other