Ontology highlight
ABSTRACT:
SUBMITTER: Hakhverdyan Z
PROVIDER: S-EPMC4449307 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Nature methods 20150504 6
We must reliably map the interactomes of cellular macromolecular complexes in order to fully explore and understand biological systems. However, there are no methods to accurately predict how to capture a given macromolecular complex with its physiological binding partners. Here, we present a screening method that comprehensively explores the parameters affecting the stability of interactions in affinity-captured complexes, enabling the discovery of physiological binding partners in unparalleled ...[more]