Ontology highlight
ABSTRACT:
SUBMITTER: Mastrangelo A
PROVIDER: S-EPMC4451265 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Mastrangelo Andrea A Colasanti Tania T Barbati Cristiana C Pecani Arbi A Sabatinelli Danilo D Pendolino Monica M Truglia Simona S Massaro Laura L Mancini Riccardo R Miranda Francesca F Spinelli Francesca Romana FR Conti Fabrizio F Alessandri Cristiano C
Journal of immunology research 20150518
The definition of posttranslational modification (PTM) encompasses a wide group of chemical reactions that allow modification and modulation of protein functions. The regulation of PTMs is crucial for the activity and survival of the cells. Dysregulation of PTMs has been observed in several pathological conditions, including rheumatoid arthritis (RA). RA is a systemic autoimmune disease primarily targeting the joints. The three PTMs mainly involved in this disease are glycosylation, citrullinati ...[more]