Ontology highlight
ABSTRACT:
SUBMITTER: Zhang G
PROVIDER: S-EPMC4458899 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Zhang Gang G Lischetti Tiziana T Hayward Daniel G DG Nilsson Jakob J
Nature communications 20150602
The spindle assembly checkpoint (SAC) ensures proper chromosome segregation by delaying anaphase onset in response to unattached kinetochores. Checkpoint signalling requires the kinetochore localization of the Mad1-Mad2 complex that in more complex eukaryotes depends on the Rod-Zwilch-ZW10 (RZZ) complex. The kinetochore protein Zwint has been proposed to be the kinetochore receptor for RZZ, but here we show that Bub1 and not Zwint is required for RZZ recruitment. We find that the middle region o ...[more]