Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers.
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ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC4459175 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Publications
Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers.
Zhang Wei W Luo Xiao-juan XJ Niu Li-na LN Yang Hong-ye HY Yiu Cynthia K Y CK Wang Tian-da TD Zhou Li-qun LQ Mao Jing J Huang Cui C Pashley David H DH Tay Franklin R FR
Scientific reports 20150608
Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This rep ...[more]
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