Ontology highlight
ABSTRACT:
SUBMITTER: Lee H
PROVIDER: S-EPMC4459820 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Lee Hongsik H Jeong Hyeyeun H Park Sangeun S Yoo Wonbaek W Choi Soyoung S Choi Kyungmin K Lee Min-Goo MG Lee Mihwa M Cha DaeRyong D Kim Young-Sik YS Han Jeeyoung J Kim Wonkon W Park Sun-Hwa SH Oh Junseo J
EMBO molecular medicine 20150601 6
Activated hepatic stellate cells (HSCs) play a key role in liver fibrosis, and inactivating HSCs has been considered a promising therapeutic approach. We previously showed that albumin and its derivative designed for stellate cell-targeting, retinol-binding protein-albumin domain III fusion protein (referred to as R-III), inactivate cultured HSCs. Here, we investigated the mechanism of action of albumin/R-III in HSCs and examined the anti-fibrotic potential of R-III in vivo. R-III treatment and ...[more]