Ontology highlight
ABSTRACT:
SUBMITTER: Yan M
PROVIDER: S-EPMC4460818 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Yan Maomao M Chu Lingluo L Qin Bo B Wang Zhikai Z Liu Xing X Jin Changjiang C Zhang Guanglan G Gomez Marta M Hergovich Alexander A Chen Zhengjun Z He Ping P Gao Xinjiao X Yao Xuebiao X
Scientific reports 20150609
Accurate chromosome segregation during mitosis requires the physical separation of sister chromatids which depends on correct position of mitotic spindle relative to membrane cortex. Although recent work has identified the role of PLK1 in spindle orientation, the mechanisms underlying PLK1 signaling in spindle positioning and orientation have not been fully illustrated. Here, we identified a conserved signaling axis in which NDR1 kinase activity is regulated by PLK1 in mitosis. PLK1 phosphorylat ...[more]