Ontology highlight
ABSTRACT:
SUBMITTER: Hewett SJ
PROVIDER: S-EPMC4465544 | biostudies-other | 2012 Aug
REPOSITORIES: biostudies-other
European journal of neurodegenerative disease 20120801 2
Acute inflammation is a self-limiting, complex biological response mounted to combat pathogen invasion, to protect against tissue damage, and to promote tissue repair should it occur. However, unabated inflammation can be deleterious and contribute to injury and pathology. Interleukin-1β (IL-1β), a prototypical "pro-inflammatory" cytokine, is essential to cellular defense and tissue repair in nearly all tissues. With respect to brain, however, studies suggest that IL-1β has pleiotrophic effects. ...[more]