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Single-electron transmetalation: an enabling technology for secondary alkylboron cross-coupling.

ABSTRACT: Single-electron-mediated alkyl transfer affords a novel mechanism for transmetalation, enabling cross-coupling under mild conditions. Here, general conditions are reported for cross-coupling of secondary alkyltrifluoroborates with an array of aryl bromides mediated by an Ir photoredox catalyst and a Ni cross-coupling catalyst.

SUBMITTER: Primer DN

PROVIDER: S-EPMC4466116 | biostudies-other | 2015 Feb

REPOSITORIES: biostudies-other

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Single-electron transmetalation: an enabling technology for secondary alkylboron cross-coupling.

Primer David N DN Karakaya Idris I Karakaya Idris I Tellis John C JC Molander Gary A GA

Journal of the American Chemical Society 20150204 6

Single-electron-mediated alkyl transfer affords a novel mechanism for transmetalation, enabling cross-coupling under mild conditions. Here, general conditions are reported for cross-coupling of secondary alkyltrifluoroborates with an array of aryl bromides mediated by an Ir photoredox catalyst and a Ni cross-coupling catalyst. ...[more]

PMID: 25650892

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